What is CBDV?
Cannabidivarin (CBDV) is a non-psychoactive cannabinoid that will not cause the euphoric feeling of being “high.” It is found more prevalently in indica strains, specifically landrace indica strains, and strains that are lower in tetrahydrocannabinol (THC).
Although CBDV was discovered 50 years ago, research is just commencing on the possible therapeutic benefits of this cannabinoid.
Research has so far demonstrated that CBDV is found mainly in C. indica landrace strains sourced from Asia and Africa, as well as strains naturally lower in THC. Strains that are high in CBD also typically tend to be higher in CBDV.
Effects and Benefits
Research has shown that CBDV is effective in the treatment of a variety of symptoms and conditions. Examples of conditions for which CBDV is particularly effective in providing symptom relief are listed below:
- Multiple Sclerosis
The Potential Medical Benefits of CBDV
Much of the research around CBDV has centred around its effect on seizures. GW Pharmaceuticals, which developed the first FDA-approved CBD drug called Epidiolex, is actively developing a CBDV-based drug known as GPW42006 to reduce or prevent epileptic and other forms of seizures.
Their research has shown that CBDV affects the neurochemical pathway of the capsaicin receptors involved in both the onset as well as the progression of several types of epilepsy. GW reports that CBDV has shown anti-epileptic results “across a range of in vitro and in vivo models of epilepsy.”
CBDV is also showing promise in several other areas of medicine:
- CBDV may also be a powerful anti-nausea agent. Initial research on rodents shows that CBDV likely acts as an agonist to the CB1 receptors, thereby blocking the nausea response.
- In an animal study published in 2019 in the Journal of Psychopharmacology, CBDV was found to rescue memory defects in mice that have the same genetic defect as people with Rett syndrome. CBDV also helped with neurological defects, but the effects were transient.
- According to a 2018 rodent study, CBDV has shown promise in helping the neurobehavioral issues associated with Rett syndrome. Rett syndrome is caused by an X chromosome mutation that affects girls with seizures, speech issues, and muscle spasticity. Interestingly, CBDV seems to help with both the genetically determined and chemically-induced forms of this and similar diseases.
- Childhood intractable epilepsy and autism spectrum disorder (ASD) often go hand in hand. CBDV is being investigated as a potential treatment of some of the more significant ASD issues, such as repetitive behavioral problems, cognitive challenges, and communication and social functioning issues.
As mentioned above, Strains which are high in CBDV will be more present in low-THC and high-CBD strains.
These include sativas like Dance World, Royal Medic and Painkiller XL. As well as indicas like Euphoria and Medical Mass. With that being said, strains that typically have higher levels of CBD usually yield greater levels of CBDV.